Matthew Zhou

From Brain to Heart: Complications following Insular Ischemic Stroke

Central S.S.

Neuroinflammation and cardiac fibrosis are complications of stroke and cardiovascular disease respectively. This project quantifies these two complications in order to study the brain-heart interaction following an ischemic stroke in a novel rat model. Results demonstrate a significant positive correlation between neuroinflammation and cardiac fibrosis. This novel relationship could have significant clinical value in the development of alternative diagnostic techniques for heart diseases.


Canadian Society for Clinical Chemists Award
Excellence Award – Senior Bronze Medal
Western University – $1000 Entrance Scholarship
Carleton University – $1000 Entrance Scholarship
University of Ottawa  – $1000 Entrance Scholarship



My name is Matthew Zhou and I am a Grade 11 student at London Central Secondary School. My interests include music, mathematics, chess, and science. I started playing piano at the age of six and I have won several awards at both regional and provincial competitions, including a Gold medal for the top Grade 10 RCM mark in Ontario. My interest in mathematics has led me to win multiple awards in math contests. I also enjoy playing chess and I have won many awards in regional chess tournaments. My strong passion for life sciences allowed me to win a Gold medal at the Canada-Wide Science Fair last year. This year, I received the inspiration for my science fair project through my strong interest in understanding the interactions between biological systems, especially ones of a pathophysiological nature. After learning about brain-heart interactions following insular ischemic stroke, I found that a relationship existed between the neurogenic and cardiogenic factors involved. With my strong interest in life sciences, I hope to pursue a career in medicine. My advice for any newcomers to the science fair is to never ignore ideas that seem too difficult. With hard work and dedication, anything can be achieved!