{"id":13423,"date":"2017-05-20T08:59:18","date_gmt":"2017-05-20T12:59:18","guid":{"rendered":"http:\/\/tvsef.ca\/?page_id=13423"},"modified":"2026-07-27T03:19:39","modified_gmt":"2026-07-27T07:19:39","slug":"melanie-jonnalagadda","status":"publish","type":"page","link":"https:\/\/tvsef.ca\/?page_id=13423","title":{"rendered":"Melanie Jonnalagadda"},"content":{"rendered":"\n
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\r\n \"Melanie\r\n<\/div>\r\n

Melanie JonnalagaddaGlucose-Induced Expression of Endothelin1 & its Relation to Diabetic RetinopathyCatholic Central H.S.<\/h3>\r\nDiabetic retinopathy is the leading cause of vision loss around the world. Glucose-induced expression of Endothelin-1, a vasocontrictor, was studied in human retinal endothelial cells (HREC). This study shows that ET-1 expression was greater in the high glucose sample of HREC compared to the normal glucose samples, making it a suitable diagnostic marker for type 1 and 2 diabetic retinopathy.\r\n
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Award<\/th>\r\nValue<\/th>\r\n<\/tr>\r\n\r\n
Excellence Award - Senior\r\nBronze Medal\r\nSponsor: Youth Science Canada<\/td>\r\n<\/td>\r\n<\/tr>\r\n\r\n
University of Ottawa Entrance Scholarship\r\nBronze Medallist - $1000 Entrance Scholarship\r\nSponsor: University of Ottawa<\/td>\r\n$1000<\/td>\r\n<\/tr>\r\n\r\n
Western University Scholarship\r\nBronze Medallist - $1000 Entrance Scholarship\r\nSponsor: Western University<\/td>\r\n$1000<\/td>\r\n<\/tr>\r\n\r\n\r\n<\/tbody>\r\n<\/table>\r\n

Biography<\/h3>\r\nI am Melanie Jonnalagadda, a grade 11 student in the International Baccalaureate program with a passion for Sciences and Social Justice. My project, which focuses on diabetic retinopathy, was inspired upon seeing my grandmother cope with type 2 diabetes and its secondary complications. In the future, I hope to test different herbal extracts that inhibit the expression of ET-1 under hyperglycemic stress. Apart from science fair, I play competitive Basketball and Badminton and play piano. As part of my global and local community involvement, I support an international NGO, which alleviates poverty in slum areas and I raise funds for the local breakfast program. I volunteer at the London Interfaith Peace camp and also do math tutoring after school. I have received several school awards for highest grade averages, honors roll, and I am the co-founder of the STEM club at my high school. Recently, I was accepted into the prestigious SHAD valley program at the University of Waterloo. For those interested in doing a science project, my advice would be to choose a study you are passionate about, one that you will not give up on despite setbacks.","_et_gb_content_width":"","footnotes":""},"class_list":["post-13423","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t